Selected Publications

The full list of publications is available on my Google Scholar profile.
^* authors contributed equally; ^# co-corresponding authors

2026

Wang Y^*^#, Hao X^*, Yang Z^*, Goldstein AM. Artificial intelligence and detection of Hirschsprung disease. NEJM 2026, 395(1): 99-101.
Xiang S^*, Ye Y^*, Cao X, Zeng H, Guan Y, Zhu S, Liu X, Luo D, Kong Y, Shao Z, Zhang B^#, Hao X^#. Proteomic signatures and machine learning based-prediction models for cardiovascular risk in survivors of myocardial infarction. BMC Cardiovascular Disorders 2026, 26(1): 121.
Peng B, Jiang M, Li S, Chen X, Cheng S^#, Hao X^#. Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases. Journal of Biomedical Research 2026, 40(2): 172-184.
Li J^*, Yu X^*, Shen W^*, Wang Y, Wang J, Wang J, Li S, Ma X, Guo J, Dong H, Ma Y, Zhang H, Cai J, Zhang R, Yang J, Zan H, Salvi R, Shi H^#, Hao X^#, Wang H^#, Yin S^#. Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study. Hearing Research 2026, 479: 109710.

2025

Shao Z, Tang W, Wu H, Kong Y, Hao X^#. Incorporating multiple functional annotations to improve polygenic risk prediction accuracy. Cell Genomics 2025, 5(6).
Kong Y, Tang W, Kang H, Guan Y, Li S, Cao X, Shao Z, Jiang Y^#, Wang C^#, Hao X^#. Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism. Nature Communications 2025, 16(1): 6517.
Cao X, Jiang M, Guan Y, Li S, Duan C, Gong Y, Kong Y, Shao Z, Wu H, Yao X, Li B, Wang M^#, Xu H^#, Hao X^#. Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease. Nature Communications 2025, 16(1): 3473.
Lin C^*, Xia M^*, Dai Y^*, Huang Q^*, Sun Z, Zhang G, Luo R, Peng Q, Li J, Wang X, Lin H, Gao X, Tang H, Shen X, Wang S, Jin L^#, Hao X^#, Zheng Y^#. Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites. Cell Genomics 2025, 5(4).
Ran L^*, Fang Y^*, Cheng C^*, He Y, Shao Z, Kong Y, Huang H, Xu S, Luo X, Wang W^#, Hao X^#, Wang M^#. Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations. Science Advances 2025, 11(3): eadr4606.
Du Y^*, Guan Y^*, Shao Z^*, Jiang M^*, Qu M, Kong Y, Wu H, Luo D, Peng S, Li S, Cao X, Chen J^#, Ye P^#, Xia J^#, Hao X^#. Integrative genome-wide association meta-analysis of aortic aneurysm and dissection identifies five novel genes. Genomics, Proteomics & Bioinformatics 2025, 23(5).
Liu Q, Kong Y, Kang H, Jiang Y^#, Hao X^#. Circulating polyunsaturated fatty acids percentages and coronary artery disease incidence and mortality: Observational and Mendelian randomization analyses. Clinical Nutrition 2025, 48: 122-133.

2024

Cao X, Li S, Guan Y, Shao Z, Jiang M, Wang M^#, Hao X^#. Blood calcium, genetic risk, and risk of incident kidney stone: A population-based cohort study. Mayo Clinic Proceedings 2024, 99(8): 1248-1260.
Sun Y^*, Deng J^*, Ding Y, Luo S, Li S, Guan Y, Cao X, Hao X^#, Hu Y^#. Serum albumin, genetic susceptibility, and risk of venous thromboembolism. Research and Practice in Thrombosis and Haemostasis 2024, 8(5): 102509.

2023

Hao X^*^#, Shao Z^*, Zhang N^*, Jiang M^*, Cao X, Li S, Guan Y, Wang C^#. Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture. Nature Communications 2023, 14(1): 7498.
Shi X, Qu M, Jiang Y, Zhu Z, Dai C, Jiang M, Ding L, Yan Y, Wang C, Zhang X, Cheng S^#, Hao X^#. Association of immune cell composition with the risk factors and incidence of acute coronary syndrome. Clinical Epigenetics 2023, 15(1): 115.
Chen M, Li S, Zhu Z, Dai C, Hao X^#. Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. Human Genetics 2023, 142(3): 431-443.

2022

Ma J^*, Hao X^*, Nie X, Yang S, Zhou M, Wang D, Wang B, Cheng M, Ye Z, Xie Y, Wang C^#, Chen W^#. Longitudinal relationships of polycyclic aromatic hydrocarbons exposure and genetic susceptibility with blood lipid profiles. Environment international 2022, 164: 107259.
Hao X^*^#, Liang A, Plastow G, Zhang C, Wang Z, Liu J, Salzano A, Gasparrini B, Campanile G, Zhang S, Yang L^#. An integrative genomic prediction approach for predicting buffalo milk traits by incorporating related cattle QTLs. Genes 2022, 13(8): 1430.

2021

Dai C, Chen M, Wang C, Hao X^#. Deconvolution of bulk gene expression profiles with single-cell transcriptomics to develop a cell type composition-based prognostic model for acute myeloid leukemia. Frontiers in Cell and Developmental Biology 2021, 9(3137).
Wang K, Qu M, Ding L, Shi X, Wang C, Cheng S^#, Hao X^#. Liver and kidney function biomarkers, blood cell traits and risk of severe COVID-19: A Mendelian randomization study. Frontiers in Genetics 2021, 12(840).

2020

Hao X^*, Cheng S^*, Wu D^*, Wu T^#, Lin X^#, Wang C^#. Reconstruction of the full transmission dynamics of COVID-19 in Wuhan. Nature 2020, 584(7821): 420-424.
Pan A^*, Liu L^*, Wang C^*, Guo H^*, Hao X^*, Wang Q, Huang J, He N, Yu H, Lin X^#, Wei S^#, Wu T^#. Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. JAMA 2020, 323(19): 1-9.
Hao X^*^#, Wang K, Dai C, Ding Z, Yang W, Wang C, Cheng S^#. Integrative analysis of scRNA-seq and GWAS data pinpoints periportal hepatocytes as the relevant liver cell types for blood lipids. Human Molecular Genetics 2020, 29(18): 3145-3153.

Before 2020

Hao X, Zeng P, Zhang S, Zhou X^#. Identifying and exploiting trait-relevant tissues with multiple functional annotations in genome-wide association studies. PLoS Genetics 2018, 14(1): e1007186.
Hao X, Plastow G, Zhang C, Xu S, Hu Z, Yang T, Wang K, Yang H, Yin X, Liu S, Wang Z, Wang Z^#, Zhang S^#. Genome-wide association study identifies candidate genes for piglet splay leg syndrome in different populations. BMC Genetics 2017, 18(1): 64.